Hartmut B Zinser

Title: Hartmut B Zinser: Innovator in Opioid Synthesis

Introduction

Hartmut B Zinser is a notable inventor based in Schaffhausern, Switzerland. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the synthesis of opioid compounds. With a total of six patents to his name, Zinser's work has had a considerable impact on the development of important medications.

Latest Patents

Zinser's latest patents include a novel process for the synthesis of buprenorphine. This invention outlines a unique route for synthesizing the opioid receptor antagonist buprenorphine, starting from thebaine. The process involves the reaction of thebaine with a dienophile, followed by the formation of an alkylated reaction product using a Grignard reagent. Additionally, it includes the formation of a cyanamide and the deprotection of the cyanamide and phenolic-oxygen moiety. The cleavage of one or both groups is performed in the presence of an alkali or alkaline earth sulfide, culminating in derivatization with a cyclopropyl halogen and hydrogenation to yield buprenorphine. Another significant patent is directed towards the preparation of various opioid compounds, including buprenorphine, naltrexone, naloxone, nalbuphone, and nalbuphine.

Career Highlights

Throughout his career, Hartmut B Zinser has worked with prominent companies in the pharmaceutical industry. He has been associated with Tibotec Pharmaceuticals Ltd. and Janssen Pharmaceutica NV, where he has contributed to the advancement of opioid synthesis and related research.

Collaborations

Zinser has collaborated with notable professionals in the field, including Nicolaas Martha Felix Goyvaerts and Piet Tom Bert Paul Wigerinck. These collaborations have further enriched his research and development efforts.

Conclusion

Hartmut B Zinser's innovative work in the synthesis of opioid compounds has established him as a key figure in pharmaceutical chemistry. His patents reflect a commitment to advancing medical science and improving therapeutic options for patients.