Location History:
- Oak Ridge, TN (US) (1984)
- Anderson County, TN (US) (1987 - 1991)
Company Filing History:
Years Active: 1984-1991
Title: Harold W. Schmitt: Innovator in DNA Sequencing and Neutron Dosimetry
Introduction
Harold W. Schmitt is a notable inventor based in Anderson County, TN (US). He has made significant contributions to the fields of DNA sequencing and neutron dosimetry. With a total of 3 patents, his work has advanced the understanding and application of these technologies.
Latest Patents
One of Schmitt's latest patents is a DNA sequencing process using stable isotopes. This innovative method involves incorporating specific stable isotopes associated with terminators for labels in the DNA sequencing process. The process includes a step of incorporating a stable isotope in at least one of the deoxynucleoside triphosphates and/or the dideoxynucleoside triphosphates. This results in a terminated strand that contains a stable isotope, such as an isotope of sulfur. The replicated strands are then separated through gel electrophoresis, and the location of the DNA strand with the stable isotope is analyzed using resonance ionization spectroscopy. This method enhances the accuracy of the sequencing process by allowing specific labels to be assigned to each base in the dideoxynucleoside triphosphates.
Another significant patent by Schmitt is a neutron dosimeter that incorporates new methods for determining neutron dose. This dosimeter can measure less than one millirad of dose due to neutrons of all energies down to approximately 10^3 eV. The design of the dosimeter allows for an adjustable response. It utilizes the sputtering of material from a target due to neutron action, measuring the amount of sputtered material to determine the dose. The target material can include noble-gas-impregnated polycrystalline or amorphous metals. Applications of this dosimeter include personnel neutron dosimetry and stationary neutron monitors.
Career Highlights
Harold W. Schmitt is associated with Atom Sciences, Inc., where he continues to innovate and develop new technologies. His work has had a profound impact on the fields he specializes in, particularly in enhancing the accuracy and sensitivity of measurement techniques.
Collaborations
Some of Schmitt's notable coworkers include G. Samuel Hurst and James E. Parks. Their collaborative efforts have contributed to the advancements in the technologies they have developed together.
Conclusion
Harold W. Schmitt's