Company Filing History:
Years Active: 2006
Title: The Innovative Mind of Harold Alterson: Pioneering Alphavirus Methods
Introduction: Harold Alterson, based in Cary, NC, is an accomplished inventor known for his significant contributions to virology and biotechnology. With one patent to his name, he has made strides in the preparation of alphavirus particles, pushing the boundaries of current scientific knowledge and application.
Latest Patents: Alterson's key patent is titled "Alphavirus particles and methods for preparation." This innovation focuses on methods for producing alphavirus replicon particles in high yield. The process involves electroporating replicon RNAs into permissive cells, which are maintained at a relatively high density. Along with at least one helper nucleic acid that provides essential packaging functions, the method leads to the successful harvesting of alphavirus replicon particles. Utilizing a salt wash with varying concentrations of sodium chloride and other salts allows for effective particle extraction, followed by optional purification using suitable chromatographic techniques.
Career Highlights: Harold Alterson has dedicated his professional life to advancing the field of virology. His work at Alphavax, Incorporated showcases his commitment and expertise in delivering innovative solutions for the treatment of viral infections. His singular patent reflects both a deep understanding of viral mechanisms and a drive to develop practical applications based on that knowledge.
Collaborations: Throughout his career, Alterson has worked alongside notable colleagues, including Jonathan F. Smith and Kurt Iver Kamrud. These collaborations have enriched his research and contributed to further innovations in virology and similar fields.
Conclusion: Harold Alterson’s contributions through his patent on alphavirus particles exemplify the creative and scientific spirit present in today's innovators. His work not only showcases his expertise as an inventor but also highlights the importance of collaboration in advancing scientific understanding and technological solutions.