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Years Active: 2005-2020
Title: Innovations and Contributions of Hans S. Keirstead
Introduction
Hans S. Keirstead is a prominent inventor based in Irvine, CA. He has made significant contributions to the field of biomedical research, particularly in the area of stem cell therapy and immunology. With a total of 7 patents, his work has the potential to impact the treatment of various neurological and inflammatory conditions.
Latest Patents
One of his notable inventions is related to oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury. This invention provides populations of neural cells that bear markers of glial cells, such as oligodendrocytes and their precursors. The populations are generated by differentiating pluripotent stem cells under conditions that promote enrichment of cells with the desired phenotype or functional capability. Various combinations of differentiation factors and mitogens can be used to produce cell populations bearing markers of oligodendrocyte precursor cells. Upon further differentiation, these cells form complex processes characteristic of mature oligodendrocytes. The cells are capable of forming myelin sheaths and can be used therapeutically to improve the function of the central nervous system.
Another significant patent involves IP-10 antibodies and their uses. This invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity. These antibodies inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux, and inhibit IP-10-induced cell migration. The invention also includes nucleic acid molecules encoding the antibodies, expression vectors, host cells, and methods for expressing the antibodies. Additionally, it provides methods for inhibiting IP-10 activity using the antibodies, including methods for treating various inflammatory and autoimmune diseases.
Career Highlights
Hans has worked with esteemed institutions such as the University of California and Medarex Inc. His research has been pivotal in advancing our understanding of stem cell applications and therapeutic interventions.
Collaborations
Some of his notable coworkers include Gabriel I. Nistor and Shrikant Deshpande. Their collaborative efforts have contributed to the success of various research projects and innovations.
Conclusion
Hans S. Keirstead's work exemplifies the intersection of innovation and medical research. His patents and contributions continue to pave the way for advancements in treatment options for neurological and inflammatory conditions.