The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 03, 2015
Filed:
May. 23, 2012
Shrikant Deshpande, Fremont, CA (US);
Haichun Huang, Fremont, CA (US);
Mohan Srinivasan, Cupertino, CA (US);
Josephine M. Cardarelli, San Carlos, CA (US);
Changyu Wang, Fremont, CA (US);
David Passmore, Mountain View, CA (US);
Vangipuram Rangan, Pleasant Hill, CA (US);
Thomas E. Lane, Irvine, CA (US);
Hans S. Keirstead, Irvine, CA (US);
Michael T. Liu, Irvine, CA (US);
Shrikant Deshpande, Fremont, CA (US);
Haichun Huang, Fremont, CA (US);
Mohan Srinivasan, Cupertino, CA (US);
Josephine M. Cardarelli, San Carlos, CA (US);
Changyu Wang, Fremont, CA (US);
David Passmore, Mountain View, CA (US);
Vangipuram Rangan, Pleasant Hill, CA (US);
Thomas E. Lane, Irvine, CA (US);
Hans S. Keirstead, Irvine, CA (US);
Michael T. Liu, Irvine, CA (US);
Medarex, L.L.C., Princeton, NJ (US);
Abstract
The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.