Location History:
- Brig-Glis, CH (1990 - 1992)
- Flemington, NJ (US) (1993)
Company Filing History:
Years Active: 1990-1993
Title: Innovations and Contributions of Hans P Mettler
Introduction
Hans P Mettler is a notable inventor based in Brig-Glis, Switzerland. He has made significant contributions to the field of chemistry, particularly in the development of pharmaceutical agents. With a total of 10 patents, Mettler's work has had a considerable impact on the industry.
Latest Patents
Mettler's latest patents include a process for the production of 4-Amino-2-chloro-5-cyano-6-(methylthio)primidine. This compound is produced from dicyanoketene dimethyl thioacetal and cyanamide through a condensation reaction in the presence of a base, followed by cyclization with hydrochloric acid. The dicyanoketenedimeth thioacetal is synthesized by reacting malononitrile with carbon disulfide and a base, followed by methylation with dimethyl sulfate. This reaction sequence yields the pyrimidine derivative in good yield and is practically free of by-products. Another significant patent is for the production of 1-(aminomethyl)cyclohexane acetic acid, a pharmaceutical agent used as an anticonvulsant. This process involves decarbalkoxylation of a (1-cyanocyclohexyl)malonic acid dialkyl ester to obtain the corresponding (1-cyanocyclohexyl)acetic acid alkyl ester, which is then transesterified with benzyl alcohol and hydrogenated to form the final product.
Career Highlights
Hans P Mettler is currently associated with Lonza Inc., a leading global company in the life sciences sector. His work at Lonza has allowed him to focus on innovative processes that enhance pharmaceutical production.
Collaborations
Mettler has collaborated with notable colleagues such as Felix Previdoli and Lester Mills. Their combined expertise has contributed to the advancement of various projects within the company.
Conclusion
Hans P Mettler's contributions to the field of chemistry and pharmaceuticals are noteworthy. His innovative processes and collaborations have significantly impacted the industry, showcasing his dedication to advancing scientific knowledge.