The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 1990
Filed:
Aug. 30, 1989
Hans P Mettler, Brig-Glis, CH;
Gareth Griffiths, Visp, CH;
Lester Mills, Naters, CH;
Felix Previdoli, Brig, CH;
Lonza Ltd., Gampel, CH;
Abstract
2-Aza-4-(alkoxycarbonyl)spiro[4,5]-decan-3-one and a process for the production of it, starting either from cyclohexylidene malonic acid esters or cyclohexylidene cyanoalkylates. The cyclohexylidene malonic acid ester is reacted with hydrocyanic acid in the presence of a catalytic amount of alkali cyanide or with a stoichiometric amount of alkali cyanide, in an alcohol, and subsequently treated with an acid. The resultant (1-cyanocyclohexyl) malonic acid dialkyl ester is converted by catalytic hydrogenation into the product. The cyclohexylidene cyanoalkylate is reacted with a stoichiometric amount of alkali cyanide, in an alcohol or with hydrocyanic acid in the presence of a catalytic amount of an alkali cyanide. The resultant (1-cyanocyclohexyl)-cyanoacetic acid alkyl ester is reacted in an alcohol in an acid to provide (1-cyanocyclohexyl) malonic acid dialkyl ester. The later ester is converted by catalytic hydrogenation into the product. Process of using the product for the production of 1-(aminomethyl)cyclohexane acetic acid by converting the product with HCl or sulfuric acid at an elevated temperature.