Hans-Joachim Guder

Title: Innovations of Hans-Joachim Guder

Introduction

Hans-Joachim Guder is a notable inventor based in Weilheim, Germany. He has made significant contributions to the field of electrochemical diagnostics, holding a total of 11 patents. His work focuses on developing innovative methods and apparatuses for detecting analytes in various samples.

Latest Patents

Among his latest patents is an electrochemical enzyme assay, which is a diagnostic kit, method, and apparatus designed for electrochemically determining the presence or concentration of an analyte in a sample. This invention involves forming a mixture that includes the sample, an enzyme acceptor polypeptide, an enzyme donor polypeptide, and a labeled substrate. The enzyme donor polypeptide combines with the enzyme acceptor polypeptide to create an active enzyme complex, which responds to the analyte's presence or concentration in the fluid sample. The active enzyme hydrolyzes the labeled substrate, generating an electroactive label that can be oxidized at an electrode's surface. The resulting current from this oxidation can be measured and correlated to the analyte's concentration in the sample.

Another significant patent is an electrochemical sensor that contains an enzyme linked to binding molecules. This sensor features a supporting material with a noble metal surface, such as gold or palladium, to which an enzyme like glucose oxidase is bound via binding molecules. These binding molecules form a homogeneous monolayer on the metal surface, optimizing enzyme coverage and enhancing the sensor's response time and signal yield. The design also incorporates diluent molecules that improve conductivity and reduce nonspecific binding from sample solutions.

Career Highlights

Hans-Joachim Guder has worked with prominent companies in the diagnostics field, including Boehringer Mannheim GmbH and Roche Diagnostics GmbH. His experience in these organizations has contributed to his expertise in developing innovative diagnostic technologies.

Collaborations

Throughout his career, Guder has collaborated with notable colleagues such as Johann Berger and Harvey Buck. These partnerships have fostered advancements in the field of electrochemical diagnostics.

Conclusion

Hans-Joachim Guder's contributions to electrochemical diagnostics through his innovative patents and collaborations highlight his significant impact on the field. His work continues to influence the development of diagnostic technologies that enhance the detection of analytes in various samples.