Han-Gang Yu

Title: Innovations by Han-Gang Yu

Introduction

Han-Gang Yu is a notable inventor based in Stony Brook, NY, who has made significant contributions to the field of biomedical engineering. He holds three patents that focus on advancements in cardiac health monitoring and treatment. His work is characterized by innovative approaches to understanding and influencing heart function.

Latest Patents

One of Han-Gang Yu's latest patents is a high throughput biological heart rate monitor that is molecularly determined. This invention provides a chamber and system designed for assaying drug effects on heart rate. The chamber consists of a series of wells where cardiac myocytes disaggregated from neonatal animals are plated and grown under standard tissue culture conditions. When drugs are to be assayed, the cells in each well are loaded with a calcium-sensitive dye, and the beating rate is monitored with a photodiode. A drug is added in graded concentrations to each well, and the effects on rate are observed. This construct permits the use of a cell-based bioassay for studying drugs or agents that may alter cardiac rate. This invention can be utilized in high throughput screening of drugs to evaluate and predict their effects on cardiac rate and rhythm.

Another significant patent by Yu is the implantation of a biological pacemaker that is molecularly determined. This invention provides a method of inducing a current in the heart of a subject by contacting a cell of the heart with a compound in a sufficient amount to induce a current. It also offers a method of treating a cardiac condition by increasing the current expression of the cell, thereby addressing the cardiac condition in the subject.

Career Highlights

Han-Gang Yu has had a distinguished career, working at prominent institutions such as the State University of New York and Columbia University. His research and innovations have contributed to the understanding of cardiac health and the development of new therapeutic methods.

Collaborations

Throughout his career, Han-Gang Yu has collaborated with notable individuals in his field, including Michael R. Rosen and Richard B. Robinson. These collaborations have further enhanced the impact of his work in biomedical research.

Conclusion

Han-Gang Yu's contributions to cardiac health through his innovative patents demonstrate his commitment to advancing medical technology. His work not only enhances our understanding of heart function but also paves the way for new treatment options.