The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2006
Filed:
Jul. 03, 2001
Michael R. Rosen, New York, NY (US);
Richard B. Robinson, Cresskill, NJ (US);
Ira S. Cohen, Stony Brook, NY (US);
Han-gang Yu, Stony Brook, NY (US);
Michael R. Rosen, New York, NY (US);
Richard B. Robinson, Cresskill, NJ (US);
Ira S. Cohen, Stony Brook, NY (US);
Han-Gang Yu, Stony Brook, NY (US);
The Trustees of Columbia University in the City of New York, New York, NY (US);
Research Foundation of State University of New York, Stony Brook, NY (US);
Abstract
This invention provides for a chamber and system designed for use in assaying drug effects on heart rate. The chamber consists of a series of wells. Cardiac myocytes disaggregated from neonatal animals are plated onto the bottom of each well and grown under standard tissue culture conditions. When drugs are to be assayed, the cells in each well are loaded with a calcium sensitive dye and the beating rate in each is monitored with a photodiode. A drug is added in graded concentrations to each well, and equilibrated and effects on rate are observed. This construct permits use of a cell based bioassay for the study of drugs or agents that may alter cardiac rate. This invention can be used in high throughput screening of drugs to evaluate/predict their effects on cardiac rate and rhythm.