Company Filing History:
8 out of 291 
1 out of 1,935 
Years Active: 2022-2025
Title: Haitao Ji: Innovator in Cancer Research
Introduction
Haitao Ji is a prominent inventor based in Tampa, FL, known for his significant contributions to cancer research. With a total of 8 patents, he has made remarkable strides in developing innovative therapeutic strategies targeting cancer pathways.
Latest Patents
One of his latest patents involves B-catenin/B-cell Lymphoma 9 protein-protein interaction inhibiting peptidomimetics. This patent discloses a series of helical sulfono-γ-AApeptides that mimic the binding mode of the α-helical HD2 domain of B-Cell Lymphoma 9 (BCL9). These sulfono-γ-AApeptides can structurally and functionally mimic the α-helical domain of BCL9, selectively disrupting β-catenin/BCL9 protein-protein interactions (PPIs) with high potency. Notably, these peptides can enter cancer cells, bind with β-catenin, and exhibit excellent cellular activity, proving to be much more potent than the BCL9 peptide. Furthermore, enzymatic stability studies have demonstrated the remarkable stability of these helical sulfono-γ-AApeptides, showing no degradation in the presence of pronase for 24 hours, which enhances their biological potential. Another significant patent includes small molecule pyrin-domain targeted NLRP3 inflammasome inhibitors, showcasing his innovative approach to cancer treatment.
Career Highlights
Haitao Ji has worked at notable institutions, including the H. Lee Moffitt Cancer Center and Research Institute and the University of South Florida. His work in these esteemed organizations has allowed him to focus on groundbreaking research in cancer biology and therapeutics.
Collaborations
Throughout his career, Haitao Ji has collaborated with esteemed colleagues, including Alan F. List and Jianfeng Cai. These collaborations have further enriched his research and contributed to the advancement of cancer treatment strategies.
Conclusion
Haitao Ji's innovative work in cancer research, particularly through his patents, highlights his commitment to developing effective therapeutic solutions. His contributions continue to impact the field significantly, paving the way for future advancements in cancer treatment.