Company Filing History:
Years Active: 2013-2025
Title: The Innovative Contributions of Hagit Grimberg
Introduction
Hagit Grimberg is a prominent inventor based in Herzliya, Israel. She has made significant contributions to the field of drug delivery systems, particularly focusing on the trans-membrane delivery of molecules. With a total of six patents to her name, her work is paving the way for advancements in medical treatments.
Latest Patents
Among her latest patents, Grimberg has developed compounds and methods for trans-membrane delivery of molecules. This invention provides a novel delivery system for drugs across biological membranes. It includes innovative chemical conjugates that comprise the delivery system, methods for synthesizing these compounds, and techniques for utilizing the system for delivering genetic drugs into tissues and cells, both in vitro and in vivo. Another significant patent focuses on a system for delivering genetic drugs such as siRNA or antisense oligonucleotides (ASO) across biological membranes. This system utilizes a trans-membrane delivery moiety energized by the membrane's internal electrical field, along with a redox-sensitive disulfide moiety designed to release the cargo drug in the cytoplasm, thereby exerting its pharmaceutical effects at target sites.
Career Highlights
Grimberg is currently associated with Aposense Ltd., where she continues to innovate in the field of drug delivery. Her work is crucial in addressing various medical disorders through advanced delivery systems.
Collaborations
Some of her notable coworkers include Ilan Ziv and Joseph Dubrovsky, who contribute to her research and development efforts.
Conclusion
Hagit Grimberg's innovative work in drug delivery systems exemplifies the impact of her inventions on modern medicine. Her patents are instrumental in advancing therapeutic options for patients worldwide.