The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2022
Filed:
Jan. 09, 2018
Applicant:
Aposense Ltd., Petach-Tikva, IL;
Inventors:
Assignee:
Aposense Ltd, Petach Tikva, IL;
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 47/54 (2017.01); A61K 31/713 (2006.01); C07J 41/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/713 (2013.01); A61K 47/554 (2017.08); C07J 41/0072 (2013.01); C12N 2310/14 (2013.01); C12N 2310/3515 (2013.01);
Abstract
A system for delivery of drugs, and especially genetic drugs such as siRNA or antisense oligonucleotides (ASO) across biological membranes is provided. It comprises a trans-membrane delivery moiety, energized by the membrane internal electrical field, and a redox-sensitive disulfide moiety, designed to be reduced at the cytoplasm, thus releasing the cargo drug to exert its pharmaceutical effects at its target sites.