Gyo Chang Keum

Title: Gyo Chang Keum: Innovator in Lipid Nanoparticle Technology

Introduction

Gyo Chang Keum is a prominent inventor based in Seoul, South Korea. He has made significant contributions to the field of pharmaceutical technology, particularly in the development of lipid nanoparticles for drug delivery. With a total of 10 patents, his work has the potential to revolutionize the way nucleic acid drugs are delivered in vivo.

Latest Patents

One of his latest patents involves a pharmaceutical composition of lipid nanoparticles designed for delivering nucleic acid drugs that contain a trehalose derivative. This innovative composition stabilizes nucleic acid drugs and enhances their delivery within the body. The lipid nanoparticles consist of a nucleic acid drug and various lipids, including a trehalose-based lipid, an ionizable lipid, a phospholipid, and a PEG-lipid. Notably, the structure-maintaining lipid can replace commonly used cholesterol with derivatives of lithocholic acid, glycyrrhetinic acid, or diosgenin. This technology can be utilized as either a vaccine or a therapeutic agent, depending on the type of nucleic acid drug employed.

Another significant patent focuses on compounds that serve as near-infrared fluorescent probes selectively binding to tau aggregates. This invention includes a method for preparing the compound and a tau-targeting near-infrared fluorescent probe. The composition is particularly useful for diagnosing tauopathy, including Alzheimer's disease, as it selectively binds to tau aggregates without interacting with amyloid beta proteins.

Career Highlights

Gyo Chang Keum has worked with esteemed institutions such as the Korea Institute of Science and Technology and the POSTECH Academy-Industry Foundation. His research has been pivotal in advancing the understanding and application of lipid nanoparticles in medical science.

Collaborations

Throughout his career, Gyo Chang Keum has collaborated with notable colleagues, including Ae Nim Pae and Eun Kyoung Bang. These partnerships have further enriched his research and innovation efforts.

Conclusion

Gyo Chang Keum's contributions to lipid nanoparticle technology and drug delivery systems highlight his role as a leading inventor in the pharmaceutical field. His innovative patents and collaborations continue to pave the way for advancements in medical treatments and diagnostics.