Company Filing History:
3 out of 166 
1 out of 8 Years Active: 2004-2009
Title: Guoliang Yi: Innovator in Fluorescent pH Indicators and Cellular Measurement Technologies
Introduction
Guoliang Yi is a prominent inventor based in Sunnyvale, CA, known for his significant contributions to the field of fluorescent pH indicators and cellular measurement technologies. With a total of 4 patents to his name, Yi has developed innovative methods and systems that enhance the understanding of cellular processes.
Latest Patents
Among his latest patents, Yi has developed methods for using fluorescent pH indicators for intracellular assays. This invention includes systems, compositions, and methods for measuring pH, particularly in cells and organelles. The compositions feature pH-sensitive fluorescent and fluorogenic 2',7'-dialkylfluorescein derivatives, which allow for ratiometric measurement in both the excitation and emission spectra. The methods involve adding a precursor compound to a sample cell, incubating it to release the free indicator, illuminating the sample, and detecting the fluorescence response.
Another notable patent is the development of kits for measuring cellular transmembrane potential changes. This invention encompasses an improved method for measuring membrane potential using specific compounds as potentiometric probes. These probes can be utilized alongside other fluorescent indicators and are compatible with microplate reading devices, flow cytometers, and fluorometers, making them valuable tools for measuring membrane potential in live cells.
Career Highlights
Guoliang Yi has worked with several reputable companies, including Molecular Devices Corporation and MDS Analytical Technologies Inc. His experience in these organizations has allowed him to refine his skills and contribute to groundbreaking advancements in the field of cellular measurement technologies.
Collaborations
Throughout his career, Yi has collaborated with notable colleagues, including Zhenjun Diwu and Jesse J Twu. These partnerships have fostered innovation and have been instrumental in the development of his patented technologies.
Conclusion
Guoliang Yi's work in the field of fluorescent pH indicators and cellular measurement technologies has made a significant impact on scientific research. His innovative patents and collaborations highlight his dedication to advancing our understanding of cellular processes.