Company Filing History:
Years Active: 2001-2010
Title: Guofu Zhong: Innovating Antibody Catalysis in San Diego
Introduction: Guofu Zhong, located in San Diego, CA, is a prominent inventor recognized for his groundbreaking contributions to the field of antibody catalysis. With a total of five patents to his name, Zhong has significantly advanced the scientific understanding and practical application of catalytic antibodies.
Latest Patents: Zhong's latest patents include innovative work on antibody catalysis of enantio- and diastereo-selective aldol reactions. In this research, nine efficient aldolase antibodies were generated using a hapten that uniquely combines structural components for reactive immunization and forming a transition state analog of the aldol reaction. Two of these antibodies have been characterized, revealing exceptional proficiency—up to 1000-fold better than any other antibody catalyst—and showcasing enantioselective capabilities for both aldol and retro-aldol reactions. Additionally, his work on aldol condensations by catalytic antibodies demonstrates their efficiency in catalyzing a variety of intermolecular reactions, with notable instances of creating aldol condensation products through subsequent dehydration.
Career Highlights: Zhong has built a reputable career at The Scripps Research Institute, where his research focuses on enhancing the efficiency and selectivity of catalytic antibodies. His work not only expands the potential applications of these biomolecules in various chemical reactions but also contributes to the broader field of biocatalysis.
Collaborations: Throughout his distinguished career, Guofu Zhong has collaborated with notable scientists Richard A. Lerner and Carlos F. Barbas. These partnerships have enabled significant breakthroughs in the development and understanding of catalytic antibodies.
Conclusion: Guofu Zhong stands out as an innovative inventor, pushing the boundaries of antibody catalysis. His five patents reflect his dedication to scientific advancement and his efforts to improve catalytic processes, making him a valuable asset to The Scripps Research Institute and the field of biochemistry.