The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2001
Filed:
Apr. 02, 2001
Applicant:
Inventors:
Carlos F. Barbas, Del Mar, CA (US);
Richard A. Lerner, La Jolla, CA (US);
Guofu Zhong, San Diego, CA (US);
Assignee:
The Scripps Research Institute, La Jolla, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/12 ;
U.S. Cl.
CPC ...
C12N 5/12 ;
Abstract
Nine efficient aldolase antibodies were generated using hapten 2. This hapten combines, in a single molecule, structural components employed for reactive immunization with structural components employed for forming a transition state analog of the aldol reaction. Characterization of two of these antibodies reveals that they are highly proficient (up to 1000-fold better than any other antibody catalyst) and enantioselective catalysts for aldol and retro-aldol reactions and exhibit enantio- and diastereo-selectivities opposite that of antibody 38C2.