Gregory R Bashford

Title: Gregory R Bashford: Innovator in Cerebrovascular Research and Nucleic Acid Sequencing

Introduction

Gregory R Bashford is a prominent inventor based in Lincoln, NE (US). He has made significant contributions to the fields of cerebrovascular research and nucleic acid sequencing. With a total of 7 patents to his name, Bashford's work has advanced the understanding and treatment of cerebrovascular conditions.

Latest Patents

One of his latest patents is titled "Methods of evaluating cerebrovascular reactivity using transcranial Doppler." This invention provides methods for detecting compromised cerebrovascular reactivity in subjects. The method involves acquiring transcranial Doppler signals and cardiac measurements following a breath-hold maneuver. A breath-hold acceleration index is calculated based on a linear regression correlation of temporal variations of the mean velocity across all cardiac cycles during the breath-hold maneuver. The presence of compromised cerebrovascular reactivity is detected by comparing the breath-hold acceleration index of the subject to that of a healthy individual. If compromised reactivity is identified, a therapeutically effective compound is administered along with a behavioral modification regimen.

Another notable patent is "Flowcell systems for single molecule detection." This invention offers compounds, methods, and systems for sequencing nucleic acids using single molecule detection. It utilizes labeled nanoparticles that exhibit charge-switching behavior to enable real-time sequencing of DNA in a microchannel sorting system. The system allows for the detection of sequencing products as successive detectable moieties flow through a detection channel, ensuring that cleaved product molecules are detected in isolation without interference.

Career Highlights

Gregory R Bashford has worked with notable companies such as Pacific Biosciences of California, Inc. and LI-COR, Inc. His experience in these organizations has contributed to his expertise in innovative research and development.

Collaborations

Throughout his career, Bashford has collaborated with esteemed colleagues, including John G K Williams and Jiyan Chen. These partnerships have further enriched his research endeavors and have led to significant advancements in his fields of expertise.

Conclusion

Gregory R Bashford's contributions to cerebrovascular research and nucleic acid sequencing have established him as a leading inventor in these domains. His innovative patents and collaborations reflect his commitment to advancing scientific knowledge and improving patient outcomes.