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Years Active: 2007
Title: Gregory Cope: Innovator in Protein Activity Regulation
Introduction
Gregory Cope is a notable inventor based in Pasadena, CA, who has made significant contributions to the field of protein activity regulation. With a total of 2 patents, his work focuses on innovative methods for modulating protein functions, which have implications in drug design and treatment of various diseases.
Latest Patents
One of Gregory Cope's latest patents is titled "Regulation of target protein activity through modifier proteins." This invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain exhibits peptidase activity, specifically isopeptidase activity. The patent provides polypeptides and crystalline polypeptides containing the JAM domain, along with methods for screening agents that can affect the peptidase activity of these polypeptides. Additionally, it outlines methods for using the JAM domain in rational drug design and identifying agents that can influence its peptidase activity.
Another significant patent by Cope is "Modulation of COP9 signalsome isopeptidase activity." This patent presents methods for identifying agents that can either increase or decrease the isopeptidase activity of a COP9 signalsome (CSN). It also includes methods for ameliorating pathologic conditions, such as cancer or autoimmune diseases, by modulating the CSN isopeptidase activity, along with medicaments useful for treating affected subjects.
Career Highlights
Gregory Cope has worked with prestigious institutions, including the California Institute of Technology and the National Institutes of Health. His career reflects a commitment to advancing scientific knowledge and developing practical applications for his discoveries.
Collaborations
Throughout his career, Cope has collaborated with esteemed colleagues, including Raymond J. Deshaies and Rati Verma. These collaborations have likely contributed to the depth and impact of his research.
Conclusion
Gregory Cope's innovative work in protein activity regulation showcases his dedication to scientific advancement. His patents not only highlight his expertise but also pave the way for future developments in drug design and disease treatment.