The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 09, 2007
Filed:
Jan. 09, 2003
Raymond J. Deshaies, Claremont, CA (US);
Gregory Cope, Pasadena, CA (US);
Rati Verma, Pasadena, CA (US);
Xavier I. Ambroggio, Pasadena, CA (US);
Raymond J. Deshaies, Claremont, CA (US);
Gregory Cope, Pasadena, CA (US);
Rati Verma, Pasadena, CA (US);
Xavier I. Ambroggio, Pasadena, CA (US);
California Institute of Technology, Pasadena, CA (US);
Abstract
Methods for identifying agents that can increase or decrease the isopeptidase activity of a COP9 signalsome (CSN) are provided, as are agent identified using such screening assays. In addition, methods of ameliorating a pathologic condition such as a cancer or an autoimmune disease in a subject by modulating the CSN isopeptidase activity are provided, as are medicaments useful for treating a subject having such a condition.