The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 06, 2007
Filed:
Jan. 14, 2002
Gregory Cope, Pasadena, CA (US);
Rati Verma, Pasadena, CA (US);
Lakshminarayanan Aravind, Bethesda, MD (US);
Eugene V. Koonin, Bethesda, MD (US);
Raymond Deshaies, Claremont, CA (US);
Xavier Ambroggio, Pasadena, CA (US);
Gregory Cope, Pasadena, CA (US);
Rati Verma, Pasadena, CA (US);
Lakshminarayanan Aravind, Bethesda, MD (US);
Eugene V. Koonin, Bethesda, MD (US);
Raymond Deshaies, Claremont, CA (US);
Xavier Ambroggio, Pasadena, CA (US);
California Institute of Technology, Pasadena, CA (US);
National Institutes of Health, Bethesda, MD (US);
Abstract
The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain and methods of using such polypeptides to screen for agents capable of affecting the peptidase activity of the polypeptides. The present invention also provides methods of using the JAM domain for rational drug design or identifying agents capable of affecting the peptidase activity of the JAM domain.