Graham Franke

Title: Graham Franke: Innovator in Bioluminescent Metal Ion Assays

Introduction

Graham Franke is a notable inventor based in Baltimore, MD (US). He has made significant contributions to the field of biochemistry, particularly in the development of methods for detecting metal ions. His innovative approach has the potential to impact various applications, including environmental monitoring and medical diagnostics.

Latest Patents

Graham Franke holds a patent for a method titled "Bioluminescent metal ion assay." This method allows for the qualitative and quantitative determination of metal ions. It utilizes emission from fluorescence resonance energy transfer from a luciferase-carbonic anhydrase conjugate or fusion protein to an acceptor ligand in the presence of metal ions bound to the protein. This technique enables the measurement of free metal ion concentrations down to picomolar levels. Importantly, the method is relatively insensitive to contaminants, making it suitable for measuring metal ion concentrations in cells, body fluids, or environmental samples without extensive sample preparation. He has 1 patent to his name.

Career Highlights

Throughout his career, Graham Franke has demonstrated a commitment to advancing scientific knowledge and practical applications in his field. His work on bioluminescent assays showcases his innovative thinking and dedication to solving complex problems related to metal ion detection.

Collaborations

Graham has collaborated with notable colleagues, including Richard B. Thompson and Evgenia Matveeva. These partnerships have likely contributed to the development and refinement of his patented methods.

Conclusion

Graham Franke's contributions to the field of biochemistry, particularly through his patented bioluminescent metal ion assay, highlight his role as an innovative inventor. His work not only advances scientific understanding but also offers practical solutions for various applications.