Location History:
- Welwyn Garden, GB (1997)
- Bury St. Edmunds, GB (1999 - 2000)
- Welwyne Garden City, GB (2000)
- Welwyn Garden City, GB (1992 - 2001)
Company Filing History:
Years Active: 1992-2001
Title: **The Innovations of Graham A. Showell**
Introduction
Graham A. Showell, based in Welwyn Garden City, Great Britain, is a notable inventor recognized for his contributions to the field of pharmacology through his innovative patented technologies. With an impressive portfolio of 21 patents, Showell has made significant strides in developing compounds that target specific receptor subtypes in the human body, particularly focusing on therapeutic applications.
Latest Patents
Among his most recent innovations is the patent for aminocyclohexane derivatives as 5-HT receptor agonists. This class of substituted aminocyclohexane derivatives has been identified as selective agonists for 5-HT receptor subtypes. These compounds exhibit potent agonistic properties toward the human 5-HT receptor subtype while maintaining a selective affinity at least 10-fold greater relative to other 5-HT receptor subtypes. This selectivity is crucial for the treatment and prevention of clinical conditions such as migraine and associated disorders, minimizing adverse cardiovascular events—common with non-selective 5-HT receptor agonists.
In addition, Showell's work includes the development of azetidine, pyrrolidine, and piperidine derivatives as 5-HT receptor modulators, further showcasing his expertise in creating selective pharmacological agents.
Career Highlights
Graham A. Showell has been affiliated with major pharmaceutical companies, notably Merck Sharp & Dohme Corporation and Merck Sharpe & Dohme Corp. His work in these establishments has allowed him to push the boundaries of drug development and innovate treatments that are more effective and have fewer side effects.
Collaborations
Throughout his career, Showell has collaborated with esteemed colleagues such as Leslie Joseph Street and Sylvie Bourrain. These partnerships have been instrumental in driving forward his research and expanding the potential applications of his patented inventions.
Conclusion
In summary, Graham A. Showell’s contributions to the field of pharmaceuticals, marked by his extensive patent portfolio, demonstrate a commitment to advancing medical science and improving patient care. His innovative approaches addressing specific receptor interactions promise to enhance therapeutic outcomes while reducing side effects, highlighting the importance of targeted pharmacological research in modern medicine.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.