Graeme C McAlister

USPTO Granted Patents = 16 (Patent Applications = 2)

Average Co-Inventor Count = 2.0

ph-index = 4

Forward Citations = 44(Granted Patents)

Location History:

Madison, WI (US) (2014 - 2016)
Cambridge, MA (US) (2013 - 2018)
San Jose, CA (US) (2015 - 2024)

Company Filing History:

Wisconsin Alumni Research Foundation

Years Active: 2013-2024

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16 patents (USPTO):Sort by Forward CitationsExplore Patents

1. 12080535 - Methods for transferring ions between trapping devices of variable internal pressure (2024-09-03),

2. 11764043 - Methods of mass spectrometry quantitation using cleavable isobaric tags and neutral loss fragmentation (2023-09-19),

3. 11721538 - Feeding real time search results of chimeric MS2 spectra into the dynamic exclusion list (2023-08-08),

4. 11587774 - Using real time search results to dynamically exclude product ions that may be present in the master scan (2023-02-21),

5. 10804088 - Methods and system for optimizing ion transmission through a mass spectrometer (2020-10-13),

6. 10665441 - Methods and apparatus for improved tandem mass spectrometry duty cycle (2020-05-26),

7. 10453662 - Analyzing a complex sample by MS/MS using isotopically-labeled standards (2019-10-22),

8. 10145818 - Accurate and interference-free multiplexed quantitative proteomics using mass spectrometry (2018-12-04),

9. 9960027 - Analyzing a complex sample by MS/MS using isotopically-labeled standards (2018-05-01),

10. 9929003 - Ion source filter (2018-03-27),

11. 9478405 - Method to perform beam-type collision-activated dissociation in the pre-existing ion injection pathway of a mass spectrometer (2016-10-25),

12. 9437407 - Mass spectrometry for multiplexed quantitation using multiple frequency notches (2016-09-06),

13. 9053916 - Method to perform beam-type collision-activated dissociation in the pre-existing ion injection pathway of a mass spectrometer (2015-06-09),

14. 9040903 - Precursor selection using an artificial intelligence algorithm increases proteomic sample coverage and reproducibility (2015-05-26),

15. 8742333 - Method to perform beam-type collision-activated dissociation in the pre-existing ion injection pathway of a mass spectrometer (2014-06-03),

Title: The Innovative Journey of Graeme C McAlister

Introduction: Graeme C McAlister, based in San Jose, California, is an accomplished inventor known for his significant contributions to the field of mass spectrometry. With a total of 16 patents to his name, McAlister's work emphasizes advancements in ion transfer and mass spectrometry techniques.

Latest Patents: Among his latest patents, McAlister has developed methods for transferring ions between trapping devices of variable internal pressure. This mass spectrometer system includes an ion source, multipole apparatuses, and ion gates or lenses that facilitate the precise transfer of ions. The functionality of this system relies on the computer-readable instructions that manage the power supply to the electrodes, adjusting the ion transfer duration based on the properties of the ions involved.

Additionally, McAlister has innovated methods of mass spectrometry quantitation using cleavable isobaric tags. His approach addresses the issue of ratio compression in isobaric mass spectrometry tags, such as Tandem Mass Tags (TMT), by introducing a cleavable moiety. This enhancement leads to a predictable mass loss and improved purity of the tag reporter ions, thereby advancing the accuracy of mass spectrometry quantitation.

Career Highlights: McAlister's career has been marked by his tenure at notable companies such as Thermo Finnigan LLC and the Wisconsin Alumni Research Foundation. His experience in these institutions has played a crucial role in shaping his research and innovative capabilities within the mass spectrometry landscape.

Collaborations: Throughout his career, McAlister has collaborated with esteemed colleagues, notably Joshua J Coon and Steven P Gygi. These partnerships have fostered a collaborative atmosphere conducive to groundbreaking research and development within the field.

Conclusion: Graeme C McAlister stands out as a visionary inventor whose patents and innovations have made a significant impact on the field of mass spectrometry. His work continues to inspire future advancements, underlining the importance of creativity and collaboration in scientific discovery.

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2 patents pending:

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1 patent pending (EPO):

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