Company Filing History:
Years Active: 2014
Title: The Innovations of Giselle Tomayo-Castillo in Pharmaceutical Composition
Introduction: Giselle Tomayo-Castillo, an accomplished inventor based in Heredia, Costa Rica, has made significant strides in the field of pharmaceutical compositions. With her innovative approach to treating inflammatory and allergic diseases, she exemplifies the dedication and creativity of modern inventors.
Latest Patents: Giselle is credited with one patent that presents a pharmaceutical composition for the prophylaxis and therapy of inflammatory diseases, allergic diseases, or asthma. Her invention utilizes a velvet apple (A. DC.) extract as the active ingredient. This extract exhibits inhibitory activity against the nuclear translocation of NF-κB, a critical factor in inflammatory responses. The findings indicate that the velvet apple extract can suppress the production of nitric oxide (NO) and prostaglandin E (PGE), along with the expression of iNOS and COX-2. Furthermore, it inhibits the release of interleukins such as IL-1β and TNF-α, significantly down-regulating Th2-mediated IL-4 and IL-13 production. The extract was also shown to effectively inhibit eosinophil activation and suppress immunoglobulin and chemokine secretion, proven through in vivo tests on an ovalbumin-induced asthma mouse model.
Career Highlights: Giselle has a notable affiliation with the Korea Research Institute of Bioscience and Biotechnology, where she continues to contribute to groundbreaking research in her field. Her commitment to innovation is reflected in her patent, which addresses significant health challenges facing patients with inflammatory and allergic conditions.
Collaborations: Throughout her career, Giselle has collaborated with esteemed colleagues such as Kyung Seop Ahn and Ok-Kyoung Kwon. Together, they have worked on various projects that aim to enhance the understanding and treatment of allergic diseases and asthma, further showcasing the power of teamwork in scientific advancements.
Conclusion: Giselle Tomayo-Castillo's work in developing a pharmaceutical composition utilizing velvet apple extract demonstrates her innovative spirit and dedication to improving healthcare outcomes. Her contributions not only advance medical science but also highlight the impact of inventors in addressing pressing health issues.