The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2014
Filed:
Aug. 30, 2011
Kyung Seop Ahn, Daejeon, KR;
Ok-kyoung Kwon, Daejeon, KR;
Sei Ryang OH, Daejeon, KR;
Jung Hee Kim, Daejeon, KR;
Hyeong Kyu Lee, Daejeon, KR;
Mee-young Lee, Daejeon, KR;
Hwa-young Son, Daejeon, KR;
Kyoung-youl Lee, Daejeon, KR;
Soo Yong Kim, Daejeon, KR;
Giselle Tomayo-castillo, Heredia, CR;
Katia Rosales-ovares, Heredia, CR;
Rodrigo Gamez-lobo, Heredia, CR;
Kyung Seop Ahn, Daejeon, KR;
Ok-Kyoung Kwon, Daejeon, KR;
Sei Ryang Oh, Daejeon, KR;
Jung Hee Kim, Daejeon, KR;
Hyeong Kyu Lee, Daejeon, KR;
Mee-Young Lee, Daejeon, KR;
Hwa-Young Son, Daejeon, KR;
Kyoung-Youl Lee, Daejeon, KR;
Soo Yong Kim, Daejeon, KR;
Giselle Tomayo-Castillo, Heredia, CR;
Katia Rosales-Ovares, Heredia, CR;
Rodrigo Gamez-Lobo, Heredia, CR;
Abstract
Disclosed is a pharmaceutical composition for the prophylaxis and therapy of inflammatory diseases, allergic diseases, or asthma, comprising a velvet apple (A. DC.) extract as an active ingredient. Having the inhibitory activity against the nuclear translocation of NF-κB, whose level is rapidly elevated in response to inflammatory stimuli, the velvet apple extract can suppress the production of NO and PGE, the expression of iNOS and COX-2, and the release of IL-1β and TNF-α, and can significantly down regulate Th2-mediated IL-4 and IL-13 production. In addition, the extract was found to inhibit the activation of eosinophils in bronchoalveolar lavage fluid, and to suppress the secretion of immunoglobulins and chemokines in bronchoalveolar lavage fluid and blood, as measured by in vivo tests on an ovalbumin-induced asthma mouse model. Therefore, the extract can be used in the method for preventing or treating various inflammatory disorders, allergic diseases, or asthma.