Giovanni Cotticelli

Title: Giovanni Cotticelli: Innovator in Pharmaceutical Chemistry

Introduction

Giovanni Cotticelli is a notable inventor based in Cernusco sul Naviglio, Italy. He has made significant contributions to the field of pharmaceutical chemistry, holding a total of nine patents. His work primarily focuses on processes that enhance the synthesis of important pharmaceutical compounds.

Latest Patents

Among his latest patents is a process for the preparation of 5-cyanophthalide starting from 5-carboxyphthalide. This innovative process is crucial for synthesizing citalopram and its active enantiomer, S(+) citalopram, both of which are widely used in treating depression. The method involves converting 5-carboxyphthalide into the corresponding acylochloride, which is then reacted with hydroxylamine to produce hydroxamyl phthalide. This compound undergoes a dehydration reaction to yield 5-cyanophthalide. Another significant patent describes the preparation of citalopram and escitalopram through a cyclisation reaction of precursor diols in the presence of an azodicarboxylate, a phosphine, and a strong base.

Career Highlights

Giovanni has worked with several companies, including Infosint S.A. and Adorken Technology S.p.A. His experience in these organizations has allowed him to refine his skills and contribute to advancements in pharmaceutical processes.

Collaborations

Throughout his career, Giovanni has collaborated with notable professionals in the field, including Leone Dall'Asta and Raul Salvetti. These partnerships have fostered innovation and the development of new methodologies in pharmaceutical chemistry.

Conclusion

Giovanni Cotticelli's contributions to pharmaceutical chemistry through his patents and collaborations highlight his role as an influential inventor. His innovative processes continue to impact the synthesis of vital pharmaceutical compounds.