Location History:
- Nuthetal, DE (2011)
- Università del Piemonte Orientale, IT (2012)
- Novara, IT (2008 - 2013)
- Córdoba, ES (2014)
- Cordoba, ES (2016)
- Turin, IT (2014 - 2020)
Company Filing History:
2 out of 212 
2 out of 2 
2 out of 2 Years Active: 2008-2020
Title: Giovanni Appendino: Innovator in Pharmaceutical Chemistry
Introduction
Giovanni Appendino is a prominent inventor based in Turin, Italy, known for his significant contributions to pharmaceutical chemistry. With a total of 10 patents, he has made remarkable advancements in the field, particularly in the development of novel compounds with therapeutic applications.
Latest Patents
Among his latest patents, Appendino has developed hydroxamate triterpenoid derivatives. These derivatives and their compositions demonstrate the ability to bind PHD2, stabilize HIF-1α and HIF-2α proteins, and activate the HIF pathway across various cell types. They show potential in inducing angiogenesis in human endothelial vascular cells, exhibiting neuroprotective activity, and addressing conditions such as stroke, cerebral palsy, and neurodegenerative diseases. Additionally, he has created cannabigerol derivatives, which are novel compounds with high PPARγ agonistic effects. These compounds are particularly useful in treating PPARγ-related diseases, providing therapeutic options without the cytotoxic effects commonly associated with similar compounds.
Career Highlights
Throughout his career, Giovanni Appendino has worked with notable companies, including Indena S.p.a. and the Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke. His work has significantly impacted the pharmaceutical industry, particularly in the development of innovative therapeutic agents.
Collaborations
He has collaborated with esteemed colleagues such as Maik Behrens and Anne Brockhoff, contributing to a rich exchange of ideas and advancements in their respective fields.
Conclusion
Giovanni Appendino's innovative work in pharmaceutical chemistry continues to pave the way for new treatments and therapies, showcasing the importance of research and development in addressing complex health challenges.