Company Filing History:
6 out of 25 
6 out of 8 
1 out of 7 Years Active: 2007-2017
Title: Gerold Endert: Innovator in Amphoteric Liposome Technology
Introduction
Gerold Endert is a notable inventor based in Halle, Germany, recognized for his contributions to the field of liposome technology. With a total of 12 patents to his name, he has made significant advancements in the encapsulation of active agents for therapeutic applications.
Latest Patents
One of his latest patents involves the development of amphoteric liposomes, which are serum-stable mixtures of lipids capable of encapsulating active agents. This innovative mixture comprises phosphatidylcholine and phosphatidylethanolamine in a specific ratio, allowing for the encapsulation of nucleic acid therapeutics such as oligonucleotides and DNA plasmids. The amphoteric nature of these liposomes enables them to be negatively charged or neutral at physiological pH, while becoming positively charged in more acidic environments. This property can be utilized to target specific organs or sites within the body effectively.
Another significant patent focuses on components for producing amphoteric liposomes. This invention suggests the use of amphoteric lipids with isoelectric points between 4 and 9, which can be substituted on a membranous or membrane-forming amphiphilic substance. The resulting liposomes containing these compounds offer new possibilities for drug delivery systems.
Career Highlights
Throughout his career, Gerold Endert has worked with various companies, including Marina Biotech, Inc. and Novosom AG. His work has contributed to the advancement of biotechnological applications, particularly in the field of drug delivery.
Collaborations
Gerold has collaborated with notable professionals in his field, including Steffen Panzner and Frank Essler. These collaborations have further enhanced the development and application of his innovative technologies.
Conclusion
Gerold Endert's work in amphoteric liposome technology represents a significant advancement in the field of drug delivery systems. His innovative patents and collaborations continue to influence the development of effective therapeutic solutions.