The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 30, 2015
Filed:
Sep. 09, 2010
Steffen Panzner, Halle, DE;
Yvonne Kerwitz, Nordhausen, DE;
Una Rauchhaus, Halle, DE;
Silke Lutz, Halle, DE;
Gerold Endert, Halle, DE;
Steffen Panzner, Halle, DE;
Yvonne Kerwitz, Nordhausen, DE;
Una Rauchhaus, Halle, DE;
Silke Lutz, Halle, DE;
Gerold Endert, Halle, DE;
Marina Biotech, Inc., Bothell, WA (US);
Abstract
A serum-stable mixture of lipids capable of encapsulating an active agent to form a liposome, said mixture comprising phosphatidylcholine and phosphatidylethanolamine in a ratio in the range of about 0.5 to about 8. The mixture may also include pH sensitive anionic and cationic amphiphiles, such that the mixture is amphoteric, being negatively charged or neutral at pH 7.4 and positively charged at pH 4. Amphoteric liposomes comprising such a mixture may be used for encapsulating nucleic acid therapeutics, such as oligonucleotides and DNA plasmids. The drug/lipid ratio may be adjusted to target the liposomes to particular organs or other sites in the body.