Company Filing History:
Years Active: 1993
Title: Georgette Dezeny: Innovator in Immunosuppressant Development
Introduction
Georgette Dezeny is a prominent inventor based in Short Hills, NJ (US). She has made significant contributions to the field of immunosuppressants, holding a total of 5 patents. Her work focuses on developing novel agents that play a crucial role in organ transplantation and autoimmune disease management.
Latest Patents
One of her latest patents is for the C-31 desmethyl FR-900520 cyclic hemiketal immunosuppressant agent. This patent describes a process for producing a new immunosuppressant, a C-31 desmethyl, C-19/C-22 cyclic hemiketal biotransformation analog (Compound I) of FR-900520. The process utilizes novel fermentation conditions with the microorganism, Streptomyces lavendulae ATCC No. 55209. Additionally, the patent discloses the C-31 methylated derivative (Compound II) produced by enzymatic methylation using 31-O-desmethylimmunomycin O-methyl transferase (DIMT). These macrolide immunosuppressants are essential in preventing human host rejection of foreign organ transplants, including bone marrow, liver, lung, kidney, and heart transplants.
Another significant patent is for the C-21 hydroxylated FK-506 antagonist. This patent outlines a process for producing a new FK-506 antagonist agent, a C-21 hydroxylated analog of FR-900520, under novel fermentation conditions using the microorganism, Streptomyces hygroscopicus (Merck Culture Collection MA 6832) ATCC No. 55166. This macrolide antagonist is beneficial in preventing and counteracting accidental or inadvertent FK-506 overdosage in therapeutic programs designed to prevent autoimmune diseases or human host rejection of foreign organ transplants.
Career Highlights
Georgette Dezeny is currently employed at Merck & Company, Inc., where she continues to innovate in the field of immunosuppressants. Her work has had a profound impact on the medical community, particularly in enhancing the success rates of organ transplants.
Collaborations
Throughout her career, Georgette has collaborated with notable colleagues, including Byron H. Arison and Laszlo R. Treiber. These collaborations
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