Company Filing History:
Years Active: 1994-1998
Title: George A. Knesel: Innovator in Pharmaceutical Processes
Introduction
George A. Knesel is a notable inventor based in Columbia, SC (US), recognized for his contributions to the field of pharmaceuticals. He holds a total of 3 patents, showcasing his innovative approach to improving drug formulations and processes.
Latest Patents
One of Knesel's latest patents is a process for improving the flow characteristics of crystalline ibuprofen. This process involves producing crystalline ibuprofen with a specific crystal habit characterized by a particle length larger than 75 microns and a length to width aspect ratio of greater than about 4 to 1 to about 5 to 1. The method includes crystallizing ibuprofen from a saturated solution in a liquid hydrocarbon solvent by seeding and cooling the solution to a temperature between 0°C and -20°C, which helps to retard primary nucleation while promoting secondary nucleation. The crystalline ibuprofen is then separated from the resulting slurry.
Another significant patent by Knesel is for the preparation of aromatic-substituted aliphatic carboxylic acids. This process outlines a method for synthesizing these important chemical compounds, which have various applications in the pharmaceutical industry.
Career Highlights
Knesel's career is marked by his work at Albemarle Corporation, where he has made significant advancements in chemical processes. His expertise in crystallization and chemical synthesis has contributed to the development of more effective pharmaceutical products.
Collaborations
Throughout his career, Knesel has collaborated with esteemed colleagues, including Lloyd E. Goddard and Deepak R. Patil. These collaborations have fostered innovation and enhanced the quality of research and development in their field.
Conclusion
George A. Knesel's contributions to pharmaceutical processes through his patents demonstrate his commitment to innovation in the industry. His work continues to influence the development of effective drug formulations and processes.