Albemarle Corporation

George A Knesel

Lloyd E Goddard

Deepak R Patil

Patricia Pringle

A process for producing crystalline ibuprofen having a crystal habit characterized by a particle length larger than 75 microns average and a length to width aspect ratio of greater than about 4 to 1 to about 5 to 1. The process involves crystallizing ibuprofen from a saturated solution of ibuprofen in a liquid hydrocarbon solvent by seeding and cooling such solution to a temperature of about 0.degree. C. to about -20.degree. C. at a rate to retard primary nucleation and promote secondary nucleation. The crystalline ibuprofen is separated from the slurry produced from such cooling.

Process for improving flow characteristics of crystalline ibuprofen

A process for the preparation of aromatic substituted carboxylic acids is disclosed. The process comprises

Growing community of inventors

Columbia, SC, United States of America

George A Knesel