Location History:
- Coral Gables, FL (US) (2015 - 2020)
- San Francisco, CA (US) (2020)
Company Filing History:
6 out of 376 
3 out of 15,471 
1 out of 832,812 Years Active: 2015-2020
Title: **Innovations and Contributions of Geoffrey William Stone**
Introduction
Geoffrey William Stone, a distinguished inventor based in Coral Gables, FL, has made significant contributions to the fields of immunology and therapeutics. He holds an impressive portfolio of 10 patents, reflecting his innovative spirit and dedication to improving medical science. His work primarily revolves around enhancing immune responses through advanced dendritic cell therapy techniques.
Latest Patents
Stone's latest innovations focus on methods for inducing migration by dendritic cells and enhancing immune responses. One notable patent details the compositions and methods of activating dendritic cells using LMP1, as well as LMP1-activated dendritic cell-based compositions. These developments aim to utilize dendritic cell therapy effectively while providing an adjuvant function in vaccine administration. Furthermore, the inventions disclose kits for activating dendritic cells to prepare vaccine formulations. By administering dendritic cells transfected with LMP1, Stone's research promises to induce an immune response beneficial for treating cancer or infections.
Additionally, his patents include compositions that comprise an antigen linked to a TNF superfamily ligand. This invention encompasses fusion proteins that combine antigens from infectious diseases and cancer cells with TNF SuperFamily ligands, serving as vaccine adjuvants to bolster immune responses. Such innovations can be delivered as isolated proteins, direct nucleic acids in DNA vaccination, or carried by viral vectors like adenovirus, broadening their application in immunotherapy.
Career Highlights
Throughout his career, Geoffrey William Stone has been associated with notable academic institutions, including the University of Miami and the University of California. His research has consistently focused on advancing the understanding of immune mechanisms and developing therapies that leverage the body's natural defenses against diseases.
Collaborations
Stone's journey has included collaborations with influential peers such as Richard Syd Kornbluth and Sachin Gupta. Their collective expertise has undoubtedly enriched the research landscape, enabling the development of groundbreaking strategies in immunotherapy and vaccine design.
Conclusion
Geoffrey William Stone’s contributions to immunology through his innovative patents and collaborations highlight his role as a leading inventor in the field. His work, particularly in dendritic cell therapy and vaccine adjuvants, promises to pave the way for new therapeutic avenues in combating diseases, ultimately improving patient outcomes in the medical community.