The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 25, 2019

Filed:

Aug. 28, 2018
Applicant:

University of Miami, Miami, FL (US);

Inventors:

Geoffrey W. Stone, Coral Gables, FL (US);

Sachin Gupta, Miami, FL (US);

Assignee:

UNIVERSITY OF MIAMI, Miami, FL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/435 (2006.01); C07K 14/715 (2006.01); C12Q 1/68 (2018.01); A61K 38/00 (2006.01); C12N 15/81 (2006.01); C07K 14/005 (2006.01); C12N 7/00 (2006.01); C07K 14/47 (2006.01); A61K 39/245 (2006.01); C07K 14/72 (2006.01); C07K 14/705 (2006.01); C07K 14/735 (2006.01); C07K 14/725 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 39/245 (2013.01); C07K 14/47 (2013.01); C07K 14/705 (2013.01); C07K 14/7051 (2013.01); C07K 14/7056 (2013.01); C07K 14/70535 (2013.01); C07K 14/70546 (2013.01); C07K 14/70578 (2013.01); C07K 14/70596 (2013.01); C07K 14/7156 (2013.01); C07K 14/7158 (2013.01); C07K 14/723 (2013.01); C12N 7/00 (2013.01); A61K 2039/53 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C12N 2710/16234 (2013.01);
Abstract

Disclosed herein are compositions, cells, kits, and methods for inducing an immune response in a subject. The compositions can be used as vaccines or vaccine adjuvants against cancer (e.g., melanoma, glioma, prostate, breast) and infectious diseases (e.g., therapeutic and preventative vaccination for viruses), and can be used in cell-based therapies for preventing and treating disorders such as cancer and infection. The compositions, cells, kits and methods involve one or more nucleic acids that encode one or more LMPI fusion proteins (chimeric proteins), and in a typical embodiment, synergistic activation of immune responses by a combination of two or more LMPI fusion proteins.


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