Ge Wu

Title: Ge Wu: Innovator in FGFR Fusion Proteins

Introduction

Ge Wu is a prominent inventor based in La Canada, CA (US). He has made significant contributions to the field of biotechnology, particularly in the development of FGFR fusion proteins. With a total of 6 patents to his name, Wu's work focuses on innovative methods for treating proliferative disorders, including various forms of cancer.

Latest Patents

Wu's latest patents include groundbreaking inventions related to FGFR fusion proteins. One notable patent describes methods of treating disease with FGFR1 fusion proteins. This invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion molecules can be produced in CHO cells and may include deletion mutations in the extracellular domains of the FGFRs, which enhance their stability. These fusion proteins have been shown to inhibit the growth and viability of cancer cells both in vitro and in vivo. The combination of the relatively high affinity of these receptors for their ligand FGFs and the demonstrated ability of these decoy receptors to inhibit tumor growth indicates the clinical value of the compositions and methods provided.

Another significant patent involves FGFR2 fusion proteins comprising C-terminal deletion mutants of FGFR2-IIIC. Similar to the FGFR1 fusion proteins, this invention also provides methods for making and using these fusion proteins to treat proliferative disorders. The stability and efficacy of these proteins further highlight their potential in clinical applications.

Career Highlights

Ge Wu is currently associated with Five Prime Therapeutics, Inc., where he continues to advance his research and development efforts. His work has positioned him as a key figure in the biotechnology sector, particularly in the realm of cancer treatment.

Collaborations

Wu collaborates with notable colleagues, including Lewis T Williams and Elizabeth Bosch, who contribute to the innovative research environment at Five Prime Therapeutics, Inc.

Conclusion

Ge Wu's contributions to the field of biotechnology, particularly through his patents on FGFR fusion proteins, demonstrate his commitment to advancing medical science. His work holds promise for improving treatment options for patients with proliferative disorders, including cancer.