Gary Ka Leong Lee

Title: Gary Ka Leong Lee: Innovator in Gene Therapy

Introduction

Gary Ka Leong Lee is a prominent inventor based in Richmond, CA (US). He has made significant contributions to the field of gene therapy, holding a total of 6 patents. His work focuses on innovative methods and compositions that advance the understanding and treatment of various diseases.

Latest Patents

Among his latest patents is a groundbreaking invention titled "Methods and compositions for gene inactivation." This patent discloses methods for inactivating CCR-5 genes using zinc finger nucleases (ZFNs). The invention includes polynucleotides encoding ZFNs, vectors such as adenovirus (Ad) vectors, and cells that incorporate these polynucleotides. Another notable patent is "Methods and compositions for increased transgene expression." This invention describes methods for expressing nucleic acids in T cells that have been pre-exposed to a co-stimulatory signal and subsequently transduced with adenoviral vectors. The co-stimulation is provided by anti-CD3 and anti-CD28 antibodies, enhancing the efficacy of the treatment for immunological conditions and hematological malignancies.

Career Highlights

Gary has worked with notable companies in the biotechnology sector, including Sangamo Biosciences, Inc. and Sangamo Therapeutics, Inc. His experience in these organizations has allowed him to contribute to significant advancements in gene therapy and related fields.

Collaborations

Throughout his career, Gary has collaborated with esteemed colleagues such as Michael C. Holmes and Dale Ando. These partnerships have fostered innovation and have been instrumental in the development of his patented technologies.

Conclusion

Gary Ka Leong Lee is a distinguished inventor whose work in gene therapy has the potential to transform treatment methodologies for various diseases. His innovative patents and collaborations highlight his commitment to advancing medical science.