The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 2023
Filed:
Jul. 03, 2018
Applicant:
Sangamo Therapeutics, Inc., Richmond, CA (US);
Inventors:
Dale Ando, Richmond, CA (US);
Michael C. Holmes, Richmond, CA (US);
Gary Ka Leong Lee, Richmond, CA (US);
Assignee:
Sangamo Therapeutics, Inc., Brisbane, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); C07K 14/47 (2006.01); C12N 5/10 (2006.01); A61K 35/12 (2015.01); C12N 9/22 (2006.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01); C12N 15/86 (2006.01); A61P 31/18 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61K 35/12 (2013.01); C07K 14/47 (2013.01); C07K 14/4703 (2013.01); C12N 5/10 (2013.01); C12N 9/22 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); A61K 2035/124 (2013.01); A61P 31/18 (2018.01); C12N 15/86 (2013.01); C12N 2710/10343 (2013.01); C12N 2710/10345 (2013.01);
Abstract
Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.