Company Filing History:
3 out of 3,681 
2 out of 637 
2 out of 142 
Years Active: 1976-2008
Title: Gary D. Madding: Innovator in Isomer Resolution and Azapirones
Introduction
Gary D. Madding, an accomplished inventor based in Evansville, Indiana, holds a significant portfolio of eight patents. His innovative work focuses primarily on the dynamic resolution of isomers and the synthesis of azapirones, contributing vastly to the pharmaceutical and chemical industries.
Latest Patents
Among his latest patents, Madding’s dynamic resolution method stands out, enabling the enrichment of desired isomers of alpha-substituted carboxylic acids. This method involves contacting the chiral alpha-substituted carboxylic acid with a homochiral amine to form a selectively soluble salt, promoting the greater solubility of the undesired isomer. This strategic technique effectively increases the amount of the desired alpha-substituted carboxylic acid isomer through precise reaction conditions.
Additionally, Madding's process for preparing certain azapirones offers an improved method for synthesizing compounds like buspirone and gepirone. This process utilizes a novel spiroquaternary piperazinium hydroxide reacted with appropriate imides to create imidate salts, which are then converted into azapirones upon heating. This adaptation not only enhances safety but also improves efficiency, making it suitable for large-scale applications.
Career Highlights
Throughout his career, Gary D. Madding has made substantial contributions while working at prominent companies, including Bristol-Myers Squibb Company and Mead Johnson & Company. His expertise in pharmaceutical chemistry has played a crucial role in developing innovative methods that are both effective and practical.
Collaborations
Madding has collaborated with notable colleagues such as John J. Venit and Victor W. Rosso. Their combined efforts have advanced research and development initiatives, allowing for the advancement of new methodologies in drug synthesis and chemical processes.
Conclusion
Gary D. Madding continues to be a significant figure in the field of inventions, setting benchmarks in the dynamic resolution of isomers and efficient azapirone preparation. His work showcases the importance of innovation in enhancing pharmaceutical methods, paving the way for future advancements in the industry.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.