Company Filing History:
2 out of 1,327 
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1 out of 832,761 Years Active: 1999-2003
Title: Garry B Takle: Innovator in Nucleic Acid Delivery
Introduction
Garry B Takle is a notable inventor based in New York, NY (US), recognized for his contributions to the field of nucleic acid delivery. He holds a total of 4 patents, showcasing his innovative approaches to complex biological challenges.
Latest Patents
One of his latest patents focuses on the "Delivery of nucleic acids by porphyrins." This invention provides efficient methods and compositions for the targeted delivery of various compounds, including nucleic acid molecules and oligonucleotides, to cells, particularly hepatocytes. The preferred embodiment involves a negatively charged oligonucleotide that binds to a positively charged macrocycle, such as a porphyrin, which protects and delivers the oligonucleotide to specific cells and tissues. Additionally, the porphyrin exhibits anti-human hepatitis virus activity, which is significantly enhanced when combined with an antiviral compound.
Another significant patent is titled "Phenotypic conversion of cells mediated by external guide sequences." This method allows for the delivery of nucleic acids to bacterial cells without requiring manipulation of the bacteria. The process involves conjugating the nucleic acid with a cationic porphyrin and contacting it with target bacterial cells. This method can convert drug-resistant bacterial cells to drug-sensitive ones, making them susceptible to drug therapy.
Career Highlights
Garry B Takle has worked with prestigious institutions such as Yale University and Innovir Laboratories, Inc. His work has significantly advanced the understanding and application of nucleic acid delivery systems.
Collaborations
Throughout his career, Takle has collaborated with notable individuals, including Shaji T George and Allan R Goldberg. These collaborations have contributed to the development of innovative solutions in his field.
Conclusion
Garry B Takle's work in nucleic acid delivery represents a significant advancement in biotechnology. His patents reflect a commitment to addressing complex medical challenges through innovative solutions.