Location History:
- Jerusalem, IL (2013)
- Palo Alto, CA (US) (2015)
Company Filing History:
Years Active: 2013-2015
Title: Galia Blum: Innovator in Protease Imaging
Introduction
Galia Blum is a prominent inventor based in Palo Alto, California. She has made significant contributions to the field of protease imaging, with a focus on developing innovative methods and materials for studying active proteases in live cells. Her work has led to the filing of two patents, showcasing her expertise and dedication to advancing scientific research.
Latest Patents
Galia Blum's latest patents include groundbreaking technologies for imaging protease activity. One patent focuses on the imaging of protease activity in live cells using activity-based probes. These probes are designed to bind to enzymes and undergo cleavage, resulting in a fluorescent signal that indicates enzyme activity. The materials used in these probes include an acyloxymethyl ketone reactive group, amino acids for specificity, a fluorophore, and a quencher. The probes are cell-permeable and utilize a QSY7 quencher and a BODIPY dye.
Another patent involves probes for in vivo targeting of active cysteine proteases. These activity-based probes are specific to certain active cysteine proteases, such as caspase, cathepsin, and legumain, and are equipped with radioactive labels. The probes feature an acyloxymethyketone 'warhead' that selectively binds to active enzymes, along with a peptide-like structure for targeting specific proteases. The radiolabel on the probe allows for imaging, and these probes have demonstrated stability and specificity in vivo.
Career Highlights
Galia Blum is affiliated with Leland Stanford Junior University, where she continues her research and development in protease imaging. Her innovative work has garnered attention in the scientific community, contributing to advancements in understanding protease activity and its implications in various biological processes.
Collaborations
Galia has collaborated with notable colleagues, including Matthew S. Bogyo and Georges Von Degenfeld. These collaborations have further enriched her research and expanded the impact of her inventions in the field.
Conclusion
Galia Blum is a trailblazer in the realm of protease imaging, with her patents reflecting her commitment to scientific innovation. Her contributions are paving the way for new discoveries in the understanding of proteases and their roles in biological systems.