The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2013
Filed:
Apr. 03, 2009
Matthew S. Bogyo, Redwood City, CA (US);
Galia Blum, Jerusalem, IL;
Alicia Berger, San Francisco, CA (US);
Zhen Cheng, Stanford, CA (US);
Sanjiv S. Gambhir, Stanford, CA (US);
Matthew S. Bogyo, Redwood City, CA (US);
Galia Blum, Jerusalem, IL;
Alicia Berger, San Francisco, CA (US);
Zhen Cheng, Stanford, CA (US);
Sanjiv S. Gambhir, Stanford, CA (US);
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Abstract
Activity-based probes, which are specific for certain active cysteine proteases (caspase, cathepsin and legumain) and carry radioactive labels, are disclosed. The present probes comprise an acyloxymethyketone (AOMK) 'warhead' that binds only to active enzyme. The probes further comprise peptide-like structure that targets the probe to a specific cysteine protease or protease family, and a radiolabel on the probe, which is bound to the targeted enzyme. It has been found that the present probes are stable in vivo and give specific target images distinguishable over background. The preferred probes are labeled with a positron-emitting agent such asCu,I (SPECT) andTc (PET). The probes show in vivo half-life and stability well suited for imaging.