Gabrielle Beth Fredman

Title: Innovations of Gabrielle Beth Fredman

Introduction

Gabrielle Beth Fredman is a notable inventor based in New York, NY (US). She has made significant contributions to the field of biomedical engineering, particularly in the development of targeted therapies. Her innovative work focuses on creating advanced nanoparticles that can effectively address inflammation-related conditions.

Latest Patents

Gabrielle holds a patent for "Targeted polymeric inflammation-resolving nanoparticles." This invention features sub-100 micron multimodal nanoparticles that consist of four main components. The first component is a target element, such as peptides, lipids, antibodies, or small molecules, which selectively binds to specific cells, tissues, or organs. The second component is a diagnostic agent, like a fluorophore or NMR contrast agent, that enables visualization of the nanoparticles at the delivery site. The third component is an outside 'stealth' layer that helps the particles evade recognition by the immune system, thereby increasing their circulation half-life. Lastly, the fourth component is a biodegradable polymeric material that forms an inner core capable of carrying therapeutics and releasing them at a sustained rate after administration. These nanoparticles exhibit excellent stability, high loading efficiency, and the ability to encapsulate multiple agents, making them particularly effective for targeting inflammation caused by various diseases or treatments.

Career Highlights

Throughout her career, Gabrielle has worked with prestigious institutions, including Brigham and Women's Hospital and the Massachusetts Institute of Technology. Her work has been instrumental in advancing the understanding and treatment of inflammatory conditions through innovative nanoparticle technology.

Collaborations

Gabrielle has collaborated with esteemed colleagues such as Omid C Farokhzad and Xueqing Zhang. Their combined expertise has contributed to the success of her research and the development of her patented technologies.

Conclusion

Gabrielle Beth Fredman is a pioneering inventor whose work in targeted polymeric nanoparticles has the potential to revolutionize the treatment of inflammation-related diseases. Her contributions to biomedical engineering highlight the importance of innovation in improving healthcare outcomes.