Massachusetts Institute of Technology

Columbia University

The Brigham and Women's Hospital, Inc.

Gabrielle Beth Fredman

Robert Samuel Langer

Omid C Farokhzad

Ira A Tabas

Pedro M Valencia

Nazila Kamaly

Xiaoyang Xu

Xueqing Zhang

Mingming Ma

Sub-100 micron multimodal nanoparticles have four main components: 1) a target element (peptides, lipids, antibodies, small molecules, etc.) that can selectively bind to cells, tissues, or organs of the body; 2) a diagnostic agent such as a fluorophore or NMR contrast agent that allows visualization of nanoparticles at the site of delivery and/or a therapeutic or prophylactic agent; 3) an outside 'stealth' layer that allows the particles to evade recognition by immune system components and increase particle circulation half-life; and 4) a biodegradable polymeric material, forming an inner core which can carry therapeutics and release the payloads at a sustained rate after systemic, intraperitoneal, or mucosal administration. These particles possess excellent stability, high loading efficiency, multiple agent encapsulation, targeting and imaging. They are targeted to sites of, or associated with, inflammation caused by a disease, disorder; trauma, chemotherapy or radiation.

Targeted polymeric inflammation-resolving nanoparticles

Growing community of inventors

New York, NY, United States of America

Gabrielle Beth Fredman