Location History:
- Exton, PA (US) (2010)
- Philadelphia, PA (US) (2014)
- Washington Crossing, PA (US) (2011 - 2015)
Company Filing History:
9 out of 2,077 
1 out of 13 
Years Active: 2010-2015
Title: Frank A. Lewandowski: Innovator in Reversible Covalent Bonds and Allosteric Processing Inhibitors
Introduction
Frank A. Lewandowski is a notable inventor based in Washington Crossing, PA (US). He has made significant contributions to the field of drug design and molecular mechanisms, holding a total of 10 patents. His work primarily focuses on methods to measure dissociation rates for ligands that form reversible covalent bonds and the development of allosteric processing inhibitors.
Latest Patents
Among his latest patents, Lewandowski has disclosed innovative methods to measure dissociation rates for ligands that form reversible covalent bonds. This includes the crystal structure of the ligand binding domain of ERR-α in complex with a ligand that forms a reversible thioether bond to Cys325 of ERR-α. These methods provide a novel molecular mechanism for modulating the activity of ERR-α and serve as a foundation for rational drug design aimed at obtaining potent specific ligands for this new drug target. Additionally, he has developed methods of treatment using allosteric processing inhibitors for matrix metalloproteinases. This invention includes a crystal comprising a complex of the pro form of a matrix metalloprotease (proMMP) and a small-molecule allosteric processing inhibitor that inhibits the activation of the proMMP. His work in this area is crucial for designing and optimizing small-molecule allosteric processing inhibitors for treating diseases mediated by inappropriate MMP activity.
Career Highlights
Throughout his career, Frank A. Lewandowski has worked with prominent companies such as Janssen Pharmaceutica and Johnson & Johnson Pharmaceutical Research & Development, LLC. His experience in these organizations has allowed him to contribute significantly to pharmaceutical research and development.
Collaborations
Some of his notable coworkers include Cynthia M. Milligan and Richard Scott Alexander. Their collaborations have likely enhanced the innovative outcomes of their research projects.
Conclusion
Frank A. Lewandowski is a distinguished inventor whose work in reversible covalent bonds and allosteric processing inhibitors has the potential to revolutionize drug design and treatment methodologies. His contributions to the field are invaluable and continue to influence pharmaceutical advancements.