Francis Santens

Title: Francis Santens: Innovator in Glyco-engineering

Introduction

Francis Santens is a notable inventor based in Ghent, Belgium, recognized for his contributions to the field of glyco-engineering. With a total of four patents to his name, he has made significant advancements in the production of glycoproteins and their therapeutic applications.

Latest Patents

One of his latest patents is focused on genetically engineered eukaryotic cells that produce LacNAc-glycoproteins. This invention provides means and methods for producing homogeneous forms of small glycan structures that carry terminal galactose residues. Additionally, it offers glycan-conjugates based on specific coupling with galactose residues present on recombinant glycoproteins. Another significant patent relates to cells producing Fc-containing molecules with altered glycosylation patterns. This application demonstrates that Fc-containing molecules with specific glycosylation patterns have a considerably longer circulating half-life in vivo, which has therapeutic implications for reducing administration frequency without affecting efficacy.

Career Highlights

Throughout his career, Francis Santens has worked with reputable organizations such as Vib Vzw and Universiteit Gent. His work has been instrumental in advancing the understanding and application of glyco-engineering in therapeutic contexts.

Collaborations

Some of his notable coworkers include Nico Callewaert and Nico L M Callewaert, who have collaborated with him on various projects in the field.

Conclusion

Francis Santens stands out as an influential inventor in glyco-engineering, with a focus on enhancing the therapeutic potential of glycoproteins. His innovative patents and collaborations continue to shape the future of this important field.