Company Filing History:
Years Active: 1998-2000
Title: Francis J. Lenoch: Innovator in Nucleic Acid Detection Technologies
Introduction
Francis J. Lenoch is a distinguished inventor based in Madison, WI, known for his significant contributions to the field of nucleic acid detection and measurement. With a total of two patents, Lenoch has developed innovative methods that enhance the understanding of reverse transcriptase activity and nucleic acid impurities.
Latest Patents
Lenoch's latest patents include a groundbreaking "Process for reverse transcriptase activity measurement." This invention involves a series of steps starting with the mixing of a DNA primer with an RNA template to form an RNA/DNA duplex using reverse transcriptase. In this process, the RNA is subsequently removed, leading to the formation of single-stranded DNA. A fluorescent-labeled oligonucleotide is then added to hybridize to the single-stranded DNA, allowing for the measurement of fluorescence polarization to detect reverse transcriptase activity and its inhibitors.
Another significant patent is the "Method for detecting and quantitating nucleic acid impurities." This invention presents a homogeneous fluorescence-based system for measuring nucleic acids in protein solutions. The method relies on non-fluorescent dye intercalation with nucleic acids, producing fluorescence that corresponds directly to the quantity of nucleic acid present in the sample.
Career Highlights
Francis J. Lenoch's career has been marked by innovation and research excellence. He is affiliated with Panvera LLC, where he has been instrumental in advancing nucleic acid detection technologies. His work focuses on improving the accuracy and efficiency of measuring genetic materials, which has significant implications in biotechnology and pharmaceuticals.
Collaborations
Throughout his career, Lenoch has collaborated closely with notable colleagues such as Thomas J. Burke and Randall E. Bolger. Together, they have contributed to advancements in their field, leveraging their collective expertise to push the boundaries of nucleic acid research.
Conclusion
Francis J. Lenoch stands out as a key inventor whose work in nucleic acid measurement and reverse transcriptase activity has paved the way for new methodologies in scientific research. His patented innovations continue to have a lasting impact on biotechnology and molecular biology, demonstrating the vital role that inventors play in scientific advancement.