Company Filing History:
Years Active: 1994-2007
Title: Innovations and Contributions of Francine B Perler
Introduction
Francine B Perler is a notable inventor based in Brookline, MA (US). She has made significant contributions to the field of biotechnology, holding a total of 11 patents. Her work primarily focuses on the mechanisms of protein splicing and the development of diagnostic tools for heartworm infections in mammals.
Latest Patents
One of her latest patents involves the screening and use of agents that block or activate intein splicing utilizing natural or homologous exteins. This invention provides selection systems and methods for screening agents that control splicing of inteins in their native host proteins. The systems include a host cell with a chromosomal gene encoding a drug-resistant form of a target enzyme and a plasmid-borne gene that encodes a drug-sensitive form of the target enzyme. The inhibition or activation of splicing by a given reagent results in the survival or death of the host cell. Additionally, her work includes the identification of a glycoprotein from Dirofilaria immitis, which can be used in immunodiagnosis of heartworm infection.
Career Highlights
Francine B Perler is currently associated with New England Biolabs, Inc., where she continues to innovate and contribute to the field of molecular biology. Her research has led to advancements in understanding protein interactions and the development of therapeutic applications.
Collaborations
She has collaborated with notable colleagues such as Donald G Comb and William E Jack, further enhancing the impact of her research through teamwork and shared expertise.
Conclusion
Francine B Perler's contributions to biotechnology and her innovative patents highlight her role as a leading inventor in her field. Her work not only advances scientific understanding but also has practical applications in medical diagnostics.