Francescopaolo Borriello

Title: Francescopaolo Borriello: Innovator in T Cell Costimulation

Introduction

Francescopaolo Borriello is a notable inventor based in Brookline, MA (US). He has made significant contributions to the field of immunology, particularly in the area of T cell costimulation. With a total of 6 patents, his work has advanced the understanding of T cell interactions and their implications in immune responses.

Latest Patents

Borriello's latest patents focus on novel structural forms of T cell costimulatory molecules. These innovations describe nucleic acid molecules encoding B7-1, which include structural forms that either add or delete specific domains. The structural forms correspond to naturally-occurring alternatively spliced forms of T cell costimulatory molecules, which can be produced using standard recombinant DNA techniques. His patents also detail T cell costimulatory polypeptides with alternative structural domains, which can be utilized to identify agents that stimulate the expression of these molecules and components of the signal transduction pathway that leads to T cell costimulation.

Career Highlights

Throughout his career, Borriello has worked with prestigious institutions, including Brigham and Women's Hospital, Inc. His research has been pivotal in enhancing the understanding of T cell biology and its applications in therapeutic settings.

Collaborations

Francescopaolo Borriello has collaborated with esteemed colleagues such as Arlene Helen Sharpe and Gordon James Freeman. These partnerships have contributed to the advancement of research in immunology and the development of innovative solutions in the field.

Conclusion

Francescopaolo Borriello's contributions to the field of immunology through his patents and collaborations highlight his role as a significant innovator in T cell costimulation. His work continues to influence research and therapeutic strategies in immunology.