The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 2009
Filed:
Oct. 26, 2006
Arlene H. Sharpe, Brookline, MA (US);
Francescopaolo Borriello, Brookline, MA (US);
Gordon J. Freeman, Brookline, MA (US);
Lee M. Nadler, Newton, MA (US);
Arlene H. Sharpe, Brookline, MA (US);
Francescopaolo Borriello, Brookline, MA (US);
Gordon J. Freeman, Brookline, MA (US);
Lee M. Nadler, Newton, MA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
The Brigham And Women's Hospital, Inc., Boston, MA (US);
Abstract
Novel structural forms of T cell costimulatory molecules are described. These structural forms comprise a novel structural domain or have a structural domain deleted or added. The structural forms correspond to naturally-occurring alternatively spliced forms of T cell costimulatory molecules or variants thereof which can be produced by standard recombinant DNA techniques. In one embodiment, the T cell costimulatory molecule of the invention contains a novel cytoplasmic domain. In another embodiment, the T cell costimulatory molecule of the invention contains a novel signal peptide domain or has an immunoglobulin variable region-like domain deleted. The novel structural forms of T cell costimulatory molecules can be used to identify agents which stimulate the expression of alternative forms of costimulatory molecules and to identify components of the signal transduction pathway which results in costimulation of T cells.